aspirin decreases results of azilsartan by pharmacodynamic antagonism. Modify Therapy/Check Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and so have an impact on fluid homeostasis and will diminish antihypertensive outcome.
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NSAIDs could diminish the antihypertensive effect of ACE inhibitors. The system of such interactions is likely linked to the flexibility of NSAIDs to decrease the synthesis of vasodilating renal prostaglandins.
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